Beilstein J. Org. Chem.2020,16, 1947–1954, doi:10.3762/bjoc.16.161
observed in the case of 6-trifluoromethyl-2-thiouracil that afforded 2- and 3-phosphonylated 5-oxothiazolopyrimidines in a 1:1 ratio.
Keywords: chloroethynylphosphonate; heterocyclization; phosphonylatedthiazolopyrimidines; phosphonylation; thiazolopyrimidine; 2-thiouracil; Introduction
the latter [22][23][24][25][26][27][28].
Herein, we report the synthesis of a new series of phosphonylatedthiazolopyrimidines. In our studies, chloroethynylphosphonate was used as the phosphonylating agent, which allowed the formation of a thiazole ring with simultaneous phosphonylation of the latter
our opinion, the presence of a phosphorus fragment in a thiazolo[3,2-a]pyrimidine molecule significantly facilitates the determination of the structure by means of 13C, 1H, and 31P NMR spectroscopy methods.
Results and Discussion
Aiming to synthesize a new series of phosphonylatedthiazolopyrimidines
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Graphical Abstract
Figure 1:
Structure of ritanserin and setoperone drugs.